Specifications

Variant Details
Catalog IDBNCAP0371-100Supplier Catalog IDBNCAP0371-100
Size100 µlPrice N/A
Supplier N/A Package Content Each (100µl)
General
AntigenKRT77 & KRT76ClonalityMonoclonal
HostMouseReactivityChicken, Cow, Dog, Human, Monkey, Mouse, Rabbit, Rat
Clone No.AE-1 / AE-3ConjugatedConjugated
Conjugate TypeAP (Alkaline Phosphatase)IsotypeIgG
Concentration0.1 mg/mLStorage BufferPBS, 0.1% BSA, 0.05% azide

Description

Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8); 56.5 kDa (CK10); 50 kDa (CK14); 50 kDa (CK15); 48 kDa (CK16); 40 kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas. Type: Primary Antigen: KRT77 & KRT76 Clonality: Monoclonal Clone: Clone AE-1 / AE-3 Conjugation: Alkaline Phosphatase Epitope: Host: Mouse Isotype: IgG's Reactivity: Chicken, Cow, Dog, Human, Monkey, Mouse, Rabbit, Rat

For research use only.