Specifications

Variant Details
Catalog ID124602-100UGSupplier Catalog ID124602-100UG
Size100 µgPrice N/A
Supplier N/A Package Content Rabbit Anti-human CD305 polyclonal antibody SKU:124602, 100 µg
General
ClonalityPolyclonalHostRabbit
ReactivityHumanCross ReactivityHuman, Mouse
ApplicationsWestern BlotConjugatedUnconjugated
IsotypeIgGImmunogenFull length human LAIR1, aa1-287 (AAH27899).
SpecificityRecognizes human LAIR1.DilutionOptimal dilutions to be determined by the researcher.
Purification MethodPurified by Protein A affinity chromatography.GeneCD305
Protein Accession No.BC027899, AAH27899FormLiquid
Shipping TemperatureBlue IceStorage & Handling-20°C
PurityAffinity Purified

Description

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.Applications:Suitable for use in Western Blot. Other applications not tested.Recommended Dilution:Optimal dilutions to be determined by the researcher.AA Sequence:MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERESRSTYNDTEDVSQASPSESEARFRIDSVSEGNAGPYRCIYYKPPKWSEQSDYLELLVKETSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLLLVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARHStorage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

For research use only.