Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.Applications: Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note:Applications are based on unconjugated antibody.Note: Applications are based on unconjugated antibody.
|Catalog ID||211201-APC-100UL||Supplier Catalog ID||211201-APC-100UL|
|Supplier||N/A||Package Content||Rabbit Anti-human HDAC8 polyclonal antibody SKU:211201-APC, 100 µl|
|Reactivity||Human||Cross Reactivity||Human, Mouse, Rat|
|Applications||Immunocytochemistry, Western Blot||Conjugated||Conjugated|
|Conjugate Type||APC (Allophycocyanin)||Isotype||IgG|
|Immunogen||Recombinant protein corresponding to human HDAC8.||Specificity||Recognizes HDAC8.|
|Dilution||Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.||Purification Method||Purified by affinity chromatography.|
|Additional Information||Applications are based on unconjugated antibody.||Form||Liquid|
|Shipping Temperature||Blue Ice||Storage & Handling||4°C Do Not Freeze|
For research use only.