Specifications

Variant Details
Catalog ID211201-APC-100ULSupplier Catalog ID211201-APC-100UL
Size100 µlPrice N/A
Supplier N/A Package Content Rabbit Anti-human HDAC8 polyclonal antibody SKU:211201-APC, 100 µl
General
ClonalityPolyclonalHostRabbit
ReactivityHumanCross ReactivityHuman, Mouse, Rat
ApplicationsImmunocytochemistry, Western BlotConjugatedConjugated
Conjugate TypeAPC (Allophycocyanin)IsotypeIgG
ImmunogenRecombinant protein corresponding to human HDAC8.SpecificityRecognizes HDAC8.
DilutionWestern Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.Purification MethodPurified by affinity chromatography.
GeneHDAC8UniProtKBQ9BY41
Additional InformationApplications are based on unconjugated antibody.FormLiquid
Shipping TemperatureBlue IceStorage & Handling4°C Do Not Freeze
PurityAffinity Purified

Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.Applications: Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note:Applications are based on unconjugated antibody.Note: Applications are based on unconjugated antibody.

For research use only.