Specifications

Variant Details
Catalog ID390138-20ULSupplier Catalog ID390138-20UL
Size20 µlPrice N/A
Supplier N/A Package Content Rabbit Anti-human HSD11B2polyclonal antibody SKU:390138, 20 µl
General
ClonalityPolyclonalHostRabbit
ReactivityHumanCross ReactivityHuman
ApplicationsELISA, ImmunocytochemistryConjugatedUnconjugated
IsotypeIgGImmunogenSynthetic peptide corresponding to human HSD11B2.
SpecificityRecognizes human HSD11B2.DilutionImmunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Purification MethodPurified by immunoaffinity chromatography.GeneHSD11B2
UniProtKBP80365Protein Accession No.NP_000187
FormLiquidShipping TemperatureBlue Ice
Storage & Handling-20°CPurityAffinity Purified

Description

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. Applications: Suitable for use in ELISA, Immunohistochemistry. Other applications not tested.Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

For research use only.