This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.Applications:Suitable for use in Western Blot, FLISARecommended Dilution:FLISA: 1:1,000Western Blot: 1:100-500Storage and Stability:Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.Note: Applications are based on unconjugated antibody.
|Catalog ID||034506-PE-200UL||Supplier Catalog ID||034506-PE-200UL|
|Supplier||N/A||Package Content||Rabbit Anti-mouse Dclk1, NT polyclonal antibody SKU:034506-PE, 200 µl|
|Applications||FLISA, Western Blot||Conjugated||Conjugated|
|Conjugate Type||PE (Phycoerythrin)||Isotype||IgG|
|Immunogen||Mouse Dclk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-181 amino acids from the N-terminal region of human Mouse Dclk1.||Dilution||FLISA: 1:1,000 Western Blot: 1:100-500|
|Purification Method||Purified by Protein A affinity chromatography.||Gene||Dclk1, NT|
|UniProtKB||Q9JLM8||Protein Accession No.||NP_064362.1|
|Additional Information||Applications are based on unconjugated antibody.||Form||Liquid|
|Shipping Temperature||Blue Ice||Storage & Handling||4°C Do Not Freeze|
For research use only.