Specifications

Variant Details
Catalog ID395315-20ULSupplier Catalog ID395315-20UL
Size20 µlPrice N/A
Supplier N/A Package Content Rabbit Anti-mouse TGFB1polyclonal antibody SKU:395315, 20 µl
General
ClonalityPolyclonalHostRabbit
ReactivityMouseCross ReactivityMouse
ApplicationsImmunocytochemistryConjugatedUnconjugated
IsotypeIgGImmunogenRecombinant protein corresponding to mouse Transforming growth factor beta-1.
SpecificityRecognizes mouse TGFB1.DilutionImmunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Purification MethodPurified by immunoaffinity chromatography.GeneTGFB1
UniProtKBP01137FormLiquid
Shipping TemperatureBlue IceStorage & Handling-20°C
PurityAffinity Purified

Description

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.Applications: Suitable for use in Immunohistochemistry. Other applications not tested.Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

For research use only.